streptolysin O

streptolysin O
Oxygen-labile thiol-activated haemolysin (native toxin is 61 kD and is cleaved to form 55 kD fragment that retains activity). Haemolysis is inhibited by cholesterol, and only cells with cholesterol in their membranes are susceptible. Toxin aggregates are linked to cholesterol to form a channel 30nm diameter in the membrane, and non-osmotic lysis follows. Markedly inhibits neutrophil movement and stimulates secretion, but has little effect on monocytes.

Dictionary of molecular biology. 2004.

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  • Streptolysin O — Masse/Länge Primärstruktur 538 Aminosäuren …   Deutsch Wikipedia

  • Streptolysin — is a streptococcal hemolytic exotoxin. [DorlandsDict|seven/000101361|streptolysin] [MeshName|Streptolysin] An antibody, anti streptolysin O, can be detected in an antistreptolysin O titre.References …   Wikipedia

  • streptolysin — noun Date: 1904 an antigenic hemolysin produced by streptococci …   New Collegiate Dictionary

  • streptolysin-O — (SLO) (strep tol ī sin) A specific hemolysin produced by Streptococcus pyogenes that is inactivated by oxygen (hence the O in its name). SLO causes beta hemolysis of blood cells on agar plates incubated anaerobically …   Dictionary of microbiology

  • streptolysin-S — (SLS) A product produced by Streptococcus pyogenes that is bound to the bacterial cell but may sometimes be released. SLS causes beta hemolysis on aerobically incubated blood agar plates and can act as a leukocidin by killing leukocytes that… …   Dictionary of microbiology

  • streptolysin S — Thought to be a peptide of 28 residues: causes zone of b haemolysis around streptococcal colonies on blood agar. Mechanism of haemolysis unclear. Toxic to leucocytes, platelets, and several cell lines …   Dictionary of molecular biology

  • streptolysin — /strep teuh luy sin/, n. Bacteriol. a type of hemolysin produced by certain species of streptococcus. [1900 05; STREPTO (repr. generic names which begin with this element, as Streptococcus) + (HEMO)LYSIN] * * * …   Universalium

  • streptolysin — noun Any of exotoxins that destroy red blood cells by breaking their membranes, and are produced by certain strains of streptococcus …   Wiktionary

  • streptolysin — A hemolysin produced by streptococci. s. O a hemolysin that is produced by β hemolytic streptococci and is hemolytically active only in the reduced state; anti s. O produced during infection is of diagnostic significance. * * * strep·to·ly·sin… …   Medical dictionary

  • Streptolysin — Strep|to|ly|sin [↑ Strepto (2) u. ↑ Lysin (2)]: ↑ Hämolysin. * * * Strep|to|ly|sin, das; s, e [zu griech. lýein = (auf)lösen] (Med.): von Streptokokken gebildetes Gift, das die Blutkörperchen u. den Blutfarbstoff auflöst …   Universal-Lexikon

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